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Protective effect of Tamarindus indica linn against paracetamol-induced hepatotoxicity in rats

Author(s): BP Pimple1, PV Kadam1, NS Badgujar1, AR Bafna1, MJ Patil2
1 Padmashree Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune - 411 018, India 2 Marathwada Mitra Mandal's College of Pharmacy, Kalewadi (Thergaon), Pune - 411 017, India

Correspondence Address:
M J Patil Marathwada Mitra Mandal's College of Pharmacy, Kalewadi (Thergaon), Pune - 411 017 India E-mail: [email protected]

Protective effect of Tamarindus indica Linn (Caesalpiniaceae) was evaluated by intoxicating the rats with paracetamol (1 g/kg p.o.) for seven days. The aqueous extracts of different parts of Tamarindus indica such as fruits, leaves (350 mg/kg p.o.) and unroasted seeds (700 mg/kg p.o.) were administered for 9 days after the third dose of paracetamol. Biochemical estimations such as aspartate transaminase, alanine transaminase, alkaline phosphatase, total bilirubin and total protein were recorded on 4 th and 13 th day. Liver weight variation, thiopentone-induced sleeping time and histopathology were studied on 13 th day. Silymarin (100 mg/kg p.o.) was used as a standard. A significant hepatoregenerative effect was observed for the aqueous extracts of tamarind leaves, fruits and unroasted seeds (p<0.05) as judged from the parameters studied.

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