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Quercetin on Bone Metabolism and Serum Osteocalcin in Osteoporotic Rats

Author(s): Xiaming Cai*, Junjun Xu and Xiang Chen
Department of Endocrinology, Affiliated Hospital of Putian University, Putian, Fujian Province 351100, China

Correspondence Address:
Xiaming Cai, Department of Endocrinology, Affiliated Hospital of Putian University, Putian, Fujian Province 351100, China, E-mail:

Osteoporosis has gradually become a common human disease. The main cause of this common disease is caused by the degradation of the internal structure of bone and soft tissues, which causes great troubles to the lives of elderly patients. Quercetin is a flavonoid drug that is commonly used to treat osteoporosis. Therefore, it is very important to study the pharmacological and clinical effects of quercetin. The purpose of this article is to solve some problems in the clinical application of quercetin and to explore the effect of quercetin on bone metabolism and serum osteocalcin in osteoporotic rats. Taking 90 rats as the research object, an animal model of osteoporosis was constructed. The rats were randomly divided into sham operation control group, ovariectomy control group and quercetin observation group. Except for the sham operation group, all rats were subjected to ovariectomy, and the rats in the quercetin observation group were given quercetin drug intervention. 1 w later, all rats were tested for bone metabolism and serum osteocalcin levels, and related data were recorded and analyzed. The results of the study showed that with the intervention of quercetin, the bone metabolism index of osteoporosis rats increased from the original (53.49±3.41) to (86.27.2±4.22), and the serum calcium level from the original (16.28±0.56) μg/l increased to (37.64±2.35) μg/l, and the bone mineral density and bone tissue structure of rats also improved accordingly. It can be seen that quercetin can promote bone metabolism in osteoporotic rats, increase the content of osteocalcin in rats, and have a good effect on the prevention and treatment of osteoporosis.

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