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Role of surfactant and pH in dissolution of curcumin

Author(s): SMH Rahman1, TC Telny2, TK Ravi3, S Kuppusamy3
1 Department of Pharmaceutics, PSG College of Pharmacy, Peelamedu, Coimbatore-641 004, India 2 Department of Pharmaceutical Analysis, Pulla Reddy Institute of Pharmacy, Jinnaram (M), Medak-502 313, India 3 Department of Pharmaceutics, Sri Ramakrishna Institute of Paramedical Sciences, Sarojini Noidu Road, Coimbatore-641 044, India

Correspondence Address:
SMH Rahman Department of Pharmaceutics, PSG College of Pharmacy, Peelamedu, Coimbatore-641 004 India [email protected]

Curcumin is a phytoconstituent with wide range of biological activity. It is poorly soluble in water. In the present study a new dissolution medium was developed, as there is no validated dissolution method available in the literature. The composition of the dissolution medium was selected on the basis of solubility data at 37°. Solubility data revealed that addition of surfactant may be suitable as a dissolution medium. The suitability of dissolution medium (0.5% sodium lauryl sulphate in water) relative to the other dissolution medium was evaluated. The selected dissolution media was used for the evaluation of curcumin tablets.

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