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Abstract

Screening of Aceclofenac for Cocrystallization with Nicotinamide: Theoretical and Practical Perspective

Author(s): A. S. Shete*, A. V. Yadav and R. C. Doijad
Department of Pharmaceutics, Krishna Institute of Pharmacy, Krishna Institute of Medical Sciences (Deemed To Be University), Karad, Maharashtra 415110, 1Gourishankar Institute of Pharmaceutical Education and Research, Limb Satara, Maharashtra 415002, India

Correspondence Address:
A. S. Shete, Department of Pharmaceutics, Krishna Institute of Pharmacy, Krishna Institute of Medical Sciences (Deemed To Be University), Karad, Maharashtra 415110, India, E-mail: [email protected]


In the last decade, cocrystallization has emerged as a means of tailoring the physicochemical properties, such as solubility and dissolution of biopharmaceutics classification system class-II drugs. The present investigation deals with formulation of cocrystals of Aceclofenac with nicotinamide by mechanical, solvent based techniques and solid state characterization of prepared cocrystals. Aceclofenac and nicotinamide in 1:1 molar ratio were used to formulate cocrystals by cogrinding, acetone based solution and solvent assisted cogrinding technique. The prepared formulations were characterized by powder X-ray diffractometry, differential scanning calorimetry, Fourier transform infrared spectroscopy and Raman spectroscopy and in vitro dissolution study. The formation of possible hydrogen bond motifs between aceclofenac and nicotinamide as heterosynthon like acid-amide, chloride-amide, acid-pyridine and amidechloride heterosynthon were found with improved dissolution rate. In case of cogrinding technique Raman spectroscopy doesn’t reveals the formation of any new phases and interactions these results of cogrinding technique are consistent with differential scanning calorimetry. Aceclofenac forms the cocrystals both theoretically and practically which has been strongly supported by Raman spectroscopy.

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