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Abstract

Simultaneous Determination Of Amitrptyline Hydrochloride And Chlordiazepoxide From Tablets By HPTLC

Author(s): V. M Shinde, N. M Tendolkar, B. S Desai

A simple, precise and rapid HPTLC method is developed for the simultaneous determination of amitriptyline hydrochloride and chlordiazepoxide from tablets using chlroform: methanol: ammonia (92:8:0.2 v/v) as a mobile phase. Metronidazole is used as internal standard. RF values obtained were 0.31, 0.40, 0.53, for metronidazole, chloridizepoxide and amitriptyline hydrochloride respectively.

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