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Abstract

Simultaneous estimation of mefenamic acid and ethamsylate in tablets

Author(s): G Garg, Swarnlata Saraf, S Saraf
Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur - 492 010, India

Correspondence Address:
S Saraf Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur - 492 010 India E-mail: [email protected]


The simple spectrophotometric methods for the determination of mefenamic acid and ethamsylate in pharmaceutical formulations have been developed. The methods are based on the additivity of absorbances and the determination of graphical absorbance ratio at two selected wavelengths, one being the isoabsorptive point for the two drugs (301 nm) and the other being the absorption maximum of mefenamic acid (336 nm) and ethamsylate (305 nm). The Beer Lambert's law is obeyed for mefenamic acid in the concentration range 4-28 µg/ml and for ethamsylate is 10-60 µg/ml. Both the methods were found to be simple, rapid, and accurate and can be adopted in routine analysis of drugs in formulations. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies.

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