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Abstract
Simultaneous spectrophotometric estimation of atorvastatin calcium and ezetimibe in tablets
Author(s): SS Sonawane1, AA Shirkhedkar2, RA Fursule2, SJ Surana2
1 MET Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nasik - 422 003, India 2 R. C. Patel College of Pharmacy, Karvand Naka, Shirpur - 425 405, India
Correspondence Address:
A A Shirkhedkar R. C. Patel College of Pharmacy, Karvand Naka, Shirpur - 425 405 India E-mail: atul_shirkhedkar@yahoo.com
1 MET Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nasik - 422 003, India 2 R. C. Patel College of Pharmacy, Karvand Naka, Shirpur - 425 405, India
Correspondence Address:
A A Shirkhedkar R. C. Patel College of Pharmacy, Karvand Naka, Shirpur - 425 405 India E-mail: atul_shirkhedkar@yahoo.com
A simple, accurate, economical and reproducible procedure for simultaneous estimation of atorvastatin calcium and ezetimibe in their tablet dosage form has been developed using, Q-absorbance equation. The method involves, the absorbance measurement at 235.5 nm (iso-absorptive point) and 246.0 nm (λmax of atorvastatin calcium), in methanol. Both the drugs, obey Beer-Lambert's law in the concentration range of 5-25 μg/ml. The results of analysis have been validated statistically and by recovery studies.
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