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Abstract

Simultaneous UV spectrophotometric estimation of ambroxol hydrochloride and levocetirizine dihydrochloride

Author(s): S Lakshmana Prabu1, AA Shirwaikar2, Annie Shirwaikar3, C Dinesh Kumar3, G Aravind Kumar2
1Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India 2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India 3Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India

Correspondence Address:
A A Shirwaikar Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal-576 104 India E-mail: [email protected]


A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of ambroxol hydrochloride and levocetirizine dihydrochloride. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths 242 nm and 231 nm, the g max of ambroxol hydrochloride and levocetirizine dihydrochloride, respectively. Beer's law was obeyed in the concentration range 10-50 μg/ml and 8-24 μg/ml for ambroxol hydrochloride and levocetirizine dihydrochloride respectively. Results of the method were validated statistically and by recovery studies.

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