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Spectrophotometric determination of Fexofenadine hydrochloride

Author(s): K Suresh Kumar1, V Ravichandran2, MK Mohan Maruga Raja3, R Thyagu3, A Dharamsi1
1Department of Pharmaceutical Analysis, K. M. C. H. College of Pharmacy, Coimbatore-641 035, India 2 Department of Pharmaceutical Chemistry, Dr. H. S. Gour Vishwavidyalaya, Sagar-470 003, India 3 J. S. S. College of Pharmacy, Ooty-643 001, India

Correspondence Address:
K Suresh Kumar Department of Pharmaceutical Analysis, K. M. C. H. College of Pharmacy, Coimbatore-641 035 India E-mail: [email protected]

A simple and sensitive spectrophotometric method has been developed for the determination of fexofenadine hydrochloride in bulk and pharmaceutical dosage forms. The method is based on the chloroform-extractable pale yellow colour complex formed by the reaction of fexofenadine with bromothymol blue at pH 2.6. The chromogen can be estimated at 412 nm against a reagent blank. This method obeys Beer's law in the concentration range of 10-50 µg/ml of the drug. The optimum reaction conditions and other analytical parameters were also evaluated. The proposed method has been successfully applied to the analysis of bulk drugs and their dosage forms.

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