All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Studies of antiviral activity and cytotoxicity of Wrightia tinctoria and Morinda citrifolia

Author(s): P Selvam1, N Murugesh2, M Witvrouw3, E Keyaerts4, J Neyts4
1 Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil, 626 190, India 2 Institute of Pharmacology, Madurai Medical College, Madurai-625 020, India 3 Molecular Medicine, Katholieke Universiteit-Leuven and IRC Kulak Kapucijnenvoer 33, Leuven B-3000, Flanders, Belgium 4 Raga Institute for Medical Research, Katholieke Universiteit-Leuven Minderbroederstraat 10, Leuven B-3000, Belgium

Correspondence Address:
P Selvam Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil, 626 190 India [email protected]

Different extracts of leaf parts of Wrightia tinctoria and fruit powder of Morinda citrifolia have been studied against replication of HIV-1(IIIB) in MT-4 cells and HCV in Huh 5.2 cells. Chloroform extract of Wrightia tinctoria exhibited a maximum protection of 48% against the cytopathic effect of HIV-1(IIIB) in MT-4 cells. Fruit juice of Morinda citrifolia exhibited a displayed marked cytotoxic activity in lymphocyte (MT-4) cells (CC50: 0.19 mg/ml). The 50% effective concentration for inhibition of HCV subgenomic replicon replication in Huh 5-2 cells by Morinda citrifolia was 0.98 µg/ml and by chloroform extract of Wrightia tinctoria was 10 µg/ml. The concentration that reduced the growth of exponentially proliferating Huh 5-2 cells by 50% was greater than 50 µg/ml.

Full-Text | PDF

Google scholar citation report
Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report