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Study on the Clinical Value of Serum Pepsinogen II in Gastritis Detection

Author(s): Dongmei Gao, Jiaoe Chen, Yuanyuan Xia, Yu Cai, Xiaoqin Yu, Jun Zhao and Hongzhang Li*
Department of Clinical Laboratory, Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province 230032, 1Department of Gastroenterology, Sanmen People’s Hospital, Sanmen, Zhejiang 317100, 2Department of Microbiology, Anhui Medical University, Hefei, Anhui Province 230032, People’s Republic of China

Correspondence Address:
Hongzhang Li, Department of Gastroenterology, Sanmen People’s Hospital, Sanmen, Zhejiang 317100, People’s Republic of China, E-mail:

The present study aims to explore the clinical value of pepsinogen II and gastritis detection. Firstly, serum expressions of pepsinogen II in patients with Helicobacter pylori-caused gastritis, gastric ulcer and atrophic gastritis were detected using enzyme-linked immunosorbent assay, followed by statistical analysis. In comparison with the normal group, serum pepsinogen II levels were increased in the above groups (p<0.01). Next, the positive cut-off value for pepsinogen II in detecting gastritis was obtained by the receiver operating characteristic curve. When the value of pepsinogen II was 10.55 μg/l, the specificity and sensitivity was 83.6 % and 74.4 % in the diagnosis of Helicobacter pylori-causing gastritis, 81.6 % and 80.0 % in gastric ulcer and 81.6 % and 53.1 % in atrophic gastritis. Thus, pepsinogen II at 10.55 μg/l was recommended as the positive cut-off value in gastritis detection. Besides, we observed that the ribonucleic acid and protein expressions of pepsinogen II in different gastritis groups were up-regulated by Western blotting and real-time polymerase chain reaction. Moreover, the immunohistochemistry indicated that pepsinogen II was highly expressed in gastritis tissues compared with normal controls. In conclusion, pepsinogen II could be an independent indicator in gastritis detection.

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