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Synthesis and anticonvulsant activity of a new series of 1,4-dihydropyridine derivatives

Author(s): R Surendra Kumar1, A Idhayadhulla1, A Jamal Abdul Nasser1, S Kavimani2, S Indumathy2
1 P. G. and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli - 620 020, India 2 Department of Pharmacology, Mother Theresa Post Graduate and Research Institute of Health Science, Puducherry - 605 006, India

Correspondence Address:
A Jamal Abdul Nasser P. G. and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli - 620 020 India E-mail: [email protected]

A series of 1,4-dihydropyridine derivatives (1a-g) were prepared from three compounds condensation of Hantzsch synthesis. A new series of 2,2'-{[4-(aryl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazinecarbothioamide (2a-g) were prepared from compounds diethyl 4-(aryl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1a-g) reacted with thiosemicarbazide to give the corresponding compounds (2a-g) by hydrazinolysis method. The synthesized compounds were confirmed by IR, 1HNMR, 13CNMR, mass spectral and elemental analyses. The newly synthesized compounds (2a-g) were screened for anticonvulsant activity against in swiss albino rat. The test was evaluated by maximal electrode induced convulsion method. Synthesized compounds were used two (50 and 100 mg/kg) concentrations. Compounds (1a-g) were inactive while compounds (2a-g) have moderate anti-convulsant activity compared with standard phenytoin drug. The compound 2,2'-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl} dihydrazinecarbothioamide (2a) has highly active compared with other compound (2b-2g).

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