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Abstract

Synthesis and antiinflammatory activity of n-aryl anthranilic acid and its derivatives

Author(s): JK Joshi, VR Patel, K Patel, D Rana, K Shah, Ronak Patel, Rajesh Patel
Department of Pharmaceutical Chemistry, Maliba Pharmacy College, Tarsadi, Surat - 394 350, India

Correspondence Address:
J K Joshi Department of Pharmaceutical Chemistry, Maliba Pharmacy College, Tarsadi, Surat - 394 350 India E-mail: [email protected]


N-aryl anthranilic acid and its derivatives (3a-f) have been synthesized via Ullmann condensation of o-chloro benzoic acid with various substituted anilines (2a-f) in the presence of cupric oxide and anhydrous potassium carbonate. All the synthesized compounds (3a-f) were characterized by mp, TLC, UV, IR, 1 H NMR and mass spectral analysis. All the synthesized compounds (3a-f) were screened for their antiinflammatory activity by carrageenan induced rat paw edema method. All the synthesized compounds (3a-f) showed significant antiinflammatory activity. Compounds 3a and 3c were found to be the most potent compounds.

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