All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis and evaluation of chitosan-Vitamin C complex

Author(s): XL Tian, DF Tian, ZY Wang, FK Mo
School of Pharmacy, Shenyang Pharmaceutical University, 110016, Shenyang, China

Correspondence Address:
F K Mo School of Pharmacy, Shenyang Pharmaceutical University, 110016, Shenyang China [email protected]


Chitosan is a biocompatible, biodegradable and non-toxic polysaccharide polymer. It dissolves in water only if the pH is lower than 6.5. To extend its range of application, many water-soluble derivatives have therefore been prepared. In this research, chitosan-vitamin C complex was synthesized and characterized with Fourier transformed infrared spectroscopy, differential scanning calorimetry and 1 H-NMR. The solubility of chitosan-vitamin C complex in distilled water was greatly improved. The •O2 - scavenging activity of chitosan-vitamin C complex was compared with chitosan and vitamin C by measuring the auto-oxidation rate of pyrogallic acid. Results showed that the scavenging activity on •O2 - by chitosan-vitamin C complex was stronger than that by CS. At low concentrations (<0.05 mg/ml), the scavenging activity of chitosan-vitamin C complex was stronger than that of vitamin C, but after certain concentrations (>0.1mg/ml), its scavenging activity was lower than that of vitamin C.

Full-Text | PDF