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Synthesis and In vitro efficacy of some halogenated imine derivatives as potential antimicrobial agents

Author(s): AK Halve, Deepti Bhadauria, B Bhaskar, R Dubey, Vasudha Sharma
School of Studies in Chemistry, Jiwaji University, Gwalior - 474 011, India

Correspondence Address:
A K Halve School of Studies in Chemistry, Jiwaji University, Gwalior - 474 011 India E-mail: [email protected]

Reaction of chloro substituted phenylazo benzenecarbaldehyde(3,4) with primary aromatic amines in ethanol afforded two series of halogenated imines viz; 2-hydroxy-5-(2'chlorophenylazo) benzylidene anilines (5a-d) and 2-hydroxy-5-(4'chlorophenylazo)benzylidene anilines (5e-h) in good yield. The chemical structures were confirmed by IR, 1 H NMR and elemental analysis. The in vitro antibacterial efficacy of synthesized imines (5a-h) was tested against selected screens of Gram-positive and Gram-negative microorganisms. Compound (5g) bearing 4'-chlorophenylazo moiety and 4'-chlorobenzylidineamino functionalities showed broad spectrum in vitro antibacterial activity among the series.

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