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Synthesis of novel thioureido derivatives of sulfonamides and thiosemicarbazido derivatives of coumarin as potential anticonvulsant and analgesic agents

Author(s): MA Bhat, N Siddiqui, SA Khan

Thioureido derivatives of sulfonamides (5a-f) Series-I and thiosemicarbazido derivatives of coumarins (10a-d) Series-II were synthesized. The identities of the compounds were confirmed on the basis of their spectral data and were screened for their anticonvulsant and analgesic activity. The compounds 5a and 10c showed maximum activity against MES test, whereas compounds 10b, 10c and 10d showed highly significant analgesic activity.

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