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Synthesis, Structure and Antioxidant Activity of (TetraO-acetyl-?-D-galactopyranosyl)thiosemicarbazones of Substituted Benzaldehydes

Author(s): Nguyen D Thanh, Le T Hoai

Some new substituted benzaldehyde (2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl) thiosemicarbazones were synthesised by reaction of 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl thiosemicarbazide and different substituted benzaldehydes. The reaction was performed using conventional and microwave-assisted heating methods. The structures of thiosemicarbazones were confirmed by spectroscopic (IR, 1H NMR, 13C NMR and MS) method. The antioxidant activity of these thiosemicarbazones was evaluated, in vitro and in vivo, and it’s shown that some of these compounds had significant antioxidant activity.

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