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The Crosstalk between MicroRNA-196a and Annexin-A1: A Potential Mechanism for Oral Squamous Cell Carcinoma Progression

Author(s): M. L. Duan and X. M. Du*
Department of Stomatology, Tianjin First Center Hospital, Tianjin 300192, 1Department of Maxillofacial Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041, China

Correspondence Address:
X. M. Du, Department of Maxillofacial Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041, China, E-mail:

Oral squamous cell carcinoma is the most common malignancy of the oral neoplasm, comprising for more than 90 % of all oral malignancies, as well as approximately 38 % of head and neck tumors. So, it is of great significance to find the potential therapeutic target of the disorder. The messenger ribonucleic acid and micro ribonucleic acid expression profiling was performed for oral squamous cell carcinoma patients; micro ribonucleic acid-messenger ribonucleic acid regulatory network was established; the functions of potential micro ribonucleic acid and messenger ribonucleic acid were further explored in Cal27 oral adenosquamous carcinoma cell line. Compared with normal mucosa, oral squamous cell carcinoma patients demonstrated 192 differentially expressed genes (66 were up-regulated and 126 were downregulated) and 23 differentially expressed micro ribonucleic acids (4 were up-regulated and 19 were downregulated), among which micro ribonucleic acid-196a and annexin-A1 were significant and differentially expressed. The annexin-A1 was a direct target of micro ribonucleic acid-196a supported by bioinformatics and luciferase analysis. The antagomiR-196a technique was utilized to silence the expression activity of micro ribonucleic acid-196a. By this, micro ribonucleic acid-196a was shown to modulate oral squamous cell carcinoma cellular migration, invasion and colony formation through annexin-A1. At the same time, the functions of micro ribonucleic acid-196a and annexin-A1 were closely associated with protein kinase B and mitogen-activated protein kinase signaling pathways. This integrated study hypothesized a micro ribonucleic acid-196a dependent signaling axis for oral squamous cell carcinoma and provided a beneficial reference for future clinical study.

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