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Abstract

The Influence on the Aging Patients with Cholecystitis in Terms of Postoperative Cognitive Function After Being Treated with Combination of Dexmedetomidine Remifentanil Sevoflurane Anesthesia Compatibility and Combination of Midazolam Fentanyl Isoflurane Anesthesia Compatibility

Author(s): G. CHEN*, XIAOMEI HE AND Y. ZHANG1
Department of pharmacy the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, 1Department of Anesthesiology, the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, China

Correspondence Address:
G. CHEN, Department of pharmacy the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, China, E-mail: [email protected]


This research article was conducted to compare the influence on aging patients with cholecystitis in terms of postoperative cognitive function after being treated with Dexmedetomidine+Remifentanil+Sevoflurane anesthesia compatibility and Midazolam+Fentanyl+Isoflurane anesthesia compatibility. Select 240 cases of aging patients who have undergone laparoscopic downward cholecystectomy under general anesthesia in our hospital from July 2016 to June 2018, then divide them into Group A and B, 120 cases for each group. The Group A has been injected with Dexmedetomidine+Remifentanil+Sevoflurane anesthesia compatibility, while the Group B Midazolam+Fentanyl+Isoflurane anesthesia compatibility. Observe and compare at different times Measures of mean arterial pressure, heart rate and Bispectral Index of patients in the two groups after being anesthetized; and the recovery time of spontaneous breathing, orientation and anesthesia, eye-opening time and extubating time; postoperative MMSE evaluation at different times. The difference concerning Measures of mean arterial pressure, heart rate and Bispectral Index of patients in both groups after being anesthetized is not significant (p>0.05); compared with patients in the group B, the postoperative orientation recovery of patients in Group A has shortened from 23.08±3.32 min to 17.66±5.15 min. The difference has statistical significance (p<0.05); MMSE evaluation of patients in Group A scores 24.02±1.95 and 26.40±2.06 for 2 h and 12 h after the surgery respectively and an improvement can be seen compared with that of Group B, which scores 20.84±1.63 and 22.42±1.95 respectively. The difference has statistical significance (p<0.05). For those aging patients with cholecystitis who have undergone laproscope, the recovery of cognitive function treated with Dexmedetomidine+Remifentanil+Sevoflurane anesthesia compatibility is better than Midozolam+Fentanyl+Isoflurane anesthesia compatibility.

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