Abstract

This study investigated the relation between entecavir dose and therapeutic effect in the treatment of chronic hepatitis B. About 180 chronic hepatitis B patients were enrolled as research subjects. They were randomly divided into the control group accepting 0.5 mg of entecavir and the research group accepting 1.0 mg of entecavir, each containing 90 patients. Indices monitored included hepatitis B virus-DNA, liver function (alanine aminotransferase, total bilirubin), alanine aminotransferase recurrence, hepatitis B virus-DNA negative conversion, HBeAg/HBeAb negative conversion were analyzed comparatively. After accepting different treatments, the hepatitis B virus-DNA level was lower significantly in the research group than that in the control group, p<0.05. The research group gained more significant improvement of liver function, alanine aminotransferase recurrence, hepatitis B virus-DNA negative conversion rate and HBeAg/HBeAb negative conversion rate, p<0.05. It can be concluded that entecavir is an ideal antihepatitis B viral drug, which can help patients improve their treatment efficiency and has high reliability.