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Abstract

The Role of Soluble Programmed Death Protein 1 in Immunosuppression of Sepsis and its Estimation Value in Prognosis

Author(s): J. Zhong, Xiaoyue Li, W. Zhang, D. Chen, L. Y. Zhang and Shaohong Li*
Department of Emergency, 1Department of Critical Care Medicine, Dongguan Tung Wah Hospital, No. 1, Dongcheng East Road, Dongguan Guangdong 523110, China

Correspondence Address:
Shaohong Li, Department of Emergency, Dongguan Tung Wah Hospital, No. 1, Dongcheng East Road, Dongguan Guangdong 523110, China, E-mail: [email protected]


To investigate the role of soluble programmed death protein 1 in immunosuppression of sepsis and its prognostic value. The patients were admitted from our hospital and divided into sepsis group (110), septic shock group (81) and control group (52). The relationship of soluble programmed death protein 1 and prognosis in patients with sepsis and septic shock were detected. On the 1st d and 7th d, the lymphocyte count, percentage and total T lymphocyte ratio were significantly lower and soluble programmed death protein 1 level was significantly higher than those of in the control group (p<0.05). The level of soluble programmed death protein 1 and the lymphocyte count and percentage on the 7th d were significantly higher than that of the 1st d (p<0.05). Compared with the 1st d, the immunoglobulin G, immunoglobulin A, immunoglobulin M and complement C3 were significantly increased (p<0.05). Soluble programmed death protein 1 was independently correlated with sequential organ failure score (R2=0.08, F=6.39, p<0.05) and the acute physiology and chronic health evaluation alpha score (OR=1.17, p=0.01), programmed death protein 1 level (OR=1.46, p=0.01) on the 1st d are independent risk factors for death in patients. The expression level of soluble programmed death protein 1 is related to the severity of the disease. Soluble programmed death protein 1 can effectively predict the 28 d prognosis of patients with sepsis and septic shock.

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