All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Therapeutic and Protective Effects of Pharmacological Agents on Femoral Head Osteonecrosis

Author(s): Z. ZHAO*
Department of Joint Surgery, Xintai City People’s Hospital, No. 1329, Xinfu Road, Xintai City, Shandong Province 271200, China

Correspondence Address:
Department of Joint Surgery, Xintai City People’s Hospital, No. 1329, Xinfu Road, Xintai City, Shandong Province 271200, China, E-mail: zhaozd0302@sina.com


A variety of pharmacological agents are available for the treatment of osteonecrosis of the femoral head. Nonetheless, several controversies are associated with their clinical use. Various electronic databases such as Medline (19992019) and EMBASE (1999-2019) were searched for an extensive literature review in English using various keywords including, femoral head osteonecrosis and pharmacological treatments together. The retrieved publications were carefully reviewed to find out the efficacy and safety of the pharmacological agents used for the treatment of femoral head osteonecrosis. The presently used pharmacological treatments in clinical practice for femoral head osteonecrosis included iloprost, enoxaparin, bisphosphonates, and statins. Nonetheless, studies have reported poor efficacy and several undesired effects of these agents. None of the high-level studies recommended the therapeutic and protective use of pharmacological agents in the treatment of osteonecrosis of the femoral head.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report