Abstract
TRNA-Histidine Guanylyltransferase 1 is a Potential Biomarker Involved in Immune Infiltration of Lung Adenocarcinoma and is Associated with Oxidative Stress
Department of Oncology, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province 210023, China
Correspondence Address:
Mianhua Wu, Department of Oncology, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province 210023, China, E-mail: mh_1423@163.com
Lung adenocarcinoma is a highly aggressive subtype of lung cancer with a high mortality rate, which makes the investigation of novel lung adenocarcinoma therapeutic targets essential. Since oxidative stress has been shown to be a cancer-specific deplete in the lung, which is highly associated with oxidative stress, it is crucial to investigate and assess the clinical value of oxidative stress-related target genes in lung adenocarcinoma. In the current study, we obtained 3170 differentially expressed genes via differential analysis and 1058 oxidative stress-related genes via the molecular signatures database. Upon analyzing their intersection, 207 genes were identified. tRNA-histidine guanylyltransferase 1 like protein, glutathione peroxidase 8, and mitogen-activated protein kinase 3 were identified as lung adenocarcinoma biomarkers using machine learning algorithms. The tumor immune infiltrating analysis revealed that the tRNA-histidine guanylyltransferase 1 like protein gene is associated with the infiltration of regulatory T cells. In addition, the multivariate analysis revealed that elevated tRNA-histidine guanylyltransferase 1 like protein expression is a significant, independent predictor of overall survival. Furthermore, the pan-cancer analysis revealed that elevated tRNA-histidine guanylyltransferase 1 like protein expression is related to a worse prognosis in a variety of cancers. In light of these findings, the identification of tRNA-histidine guanylyltransferase 1 like protein as a novel biological marker may shed light on potential function mechanisms and the impact of the immune microenvironment in lung adenocarcinoma.
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