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Abstract

Vitamin E Succinate Inhibits the Growth of Human Gastric Cancer Cells

Author(s): TINGZHU LAN AND XIAOHUI GUAN*
Department of Gastroenterology, Affiliated Hospital of BeiHua University, Jilin 132012, PR China

Correspondence Address:
XIAOHUI GUAN*, Department of Gastroenterology, Affiliated Hospital of BeiHua University, Jilin 132012, PR China, E-mail: [email protected]


Gastric cancer is the most common malignant tumor disease in the human digestive system. It ranks first in the incidence of cancer-related diseases in China. It is a serious threat to the health of Chinese people. Vitamin E Succinate is a natural Vitamin E derivative and has been confirmed to have an inhibitory effect on tumor cell growth. Based on this, the article explores the effect of Vitamin E Succinate on inhibiting the growth of human gastric cancer cells and aims to provide a reference for the clinical diagnosis and treatment of gastric cancer. This article first systematically introduces Vitamin E Succinate and the related theoretical knowledge of gastric cancer and lays a sufficient theoretical foundation for the following research on Vitamin E Succinate inhibiting the growth of human gastric cancer cells and inducing apoptosis of gastric cancer cells. The human gastric cancer cell specimens and Vitamin E Succinate solution were formulated and the effect of Vitamin E Succinate on the growth of human gastric cancer cells was tested. According to the concentration of Vitamin E Succinate, the gastric cancer cells in the experiment were divided into Vitamin E Succinate 10 mg/ml dose group, Vitamin E Succinate 10 mg/ml dose group, Vitamin E Succinate 15 mg/ml dose group and the blank control group, the growth curve of gastric cancer cells, cell colony determination, cell division index determination and cell 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide detection and analysis were used to compare the changes in cell growth between different dose groups; the final result is that Vitamin E Succinate has a significant inhibitory effect on the growth of gastric cancer cells (p<0.05)and as the dose concentration increases and the treatment time increases, its inhibitory effect on the cells is more significant.

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