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Volatile Composition and Cytotoxic Activity of Aerial Parts of Crassocephalum crepidioides growing in Western Himalaya, India

Author(s): Soni Thakur1, R. Koundal1, D. Kumar2, A. K. Maurya1, Y. S. Padwad2, B. Lal3 And V. K. Agnihotri1*
Academy of Scientific and Innovative Research, 1Natural Product Chemistry and Process Development Division, 2Division of Food and Nutraceuticals, 3Biodiversity Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur-176 061, India

Correspondence Address:
Academy of Scientific and Innovative Research, CSIR-Institute of Himalayan Bioresource Technology, Palampur-176 061, India, E-mail:;

The composition of the essential oil of Crassocephalum crepidioides was characterized using retention indices, gas chromatography-mass spectrometry and quantified by gas chromatography-flame ionization detector. Twenty seven components were identified, representing 91.2 % of the total oil. The essential oil of C. crepidioides was dominated by monoterpene hydrocarbons (80.9 %) with β-myrcene (65.9 %), β-phellandrene (8.8 %), α-pinene (3.1 %) and sesquiterpene hydrocarbons (4.8 %) with α-copaene (1.5 %), and α-humulene (1.5 %). Promising essential oil yield with β-myrcene as major component, suggests that crop could be considered for commercial cultivation. The obtained essential oil was tested against human cervical cancer SiHa, human oral epidermal carcinoma KB and human adenocarcinoma Colo-205 cell lines at 48 h, which showed significant results against all cell lines (59.8±3.7, 67.9±0.5 and 84.5±3.6, respectively at 100 µg/ml).

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