Abstract
Zinc Finger Protein 582 Deoxyribonucleic Acid Methylation, an Emerging Epigenetic Site in Cervical Cancer
Department of the Central Laboratory, 1Department of Clinical Pharmaceutical Research Institution, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 2Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China
Correspondence Address:
C. Fang, Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China, E-mail: fangchao412@yeah.net
Cervical cancer has become a most lethal and extensive gynecological malignancy, mainly because of the complete absence of symptoms in the early stage of the disease and the lack of early diagnostic markers. Several studies have found that deoxyribonucleic acid methylation plays an important role in the development of cervical cancer without altering the sequence of genomic deoxyribonucleic acid. Zinc finger protein 582 is on chromosome 19 and contains a Kruppel-associated box-AB region and 9 zinc finger motifs. Detection of the zinc finger protein 582 methylation in cervical precancerous lesions is helpful for the early diagnosis of cervical cancer. The level of chemotherapy increased with the increase of lesion grade and it was hypermethylated in cervical cancer tissues. It is hypothesized that the role of zinc finger protein 582 is like that of the tumor suppressor gene and the tumor gene expression decreases with an increased zinc finger protein 582 methylation level. This study aimed to describe the research progress of the zinc finger protein 582 methylation, detection in cervical cancer.
