Effects of Allium Hookeri Root Extracts on Oxidative Stress-induced Damage in Rat Cardiomyocyte Cells

Author(s): H. G. Choi, G. H. Xie, M. K. Lee, S. H. Park, S. E. Choi, K. T. Hwang, N. H. Kim, J. H. Jeong and K. H. Park*
Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, 62271, Korea, 1Department of General Surgery, YanBian University Hospital, JiLin, 133-000, China, 2Department of Cosmetology Science, 3Department of Food and Life Sciences, Nambu University, Gwangju, 62271, 4Hanbang Body-Fluid Research Center and College of Oriental Medicine, Wonkwang University, 460, Iksan Dae-ro, Iksan, 54538, 5Department of Medicated Diet and Food Technology, Jeonnam Provincial College, Damyang, 57337, Korea

Correspondence Address:
K. H. Park Department of Oriental Pharmaceutical Development, 1Department of Cosmetology Science, Nambu University, Gwangju, 506-706, Korea E-mail: [email protected]

The aim of this study was to investigate the bioavailability of Allium hookeri root extracts and evaluate its beneficial effects on hydrogen peroxide (H2O2)-induced oxidative stress in cultured H9C2 cardiomyocytes. After H9C2 cardiomyocytes were treated with the AHE, a substantial decrease in the H2O2-induced cytotoxicity was observed in a dose dependent manner. These results suggest that AHE has beneficial effects on cardiac dysfunction which can be used as a valuable supplement in the health-care products.

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