All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method

Author(s): S Lakshmana Prabu1, A Shirwaikar2, Annie Shirwaikar3, C Dinesh Kumar3, A Joseph4, R Kumar2
1Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, India 2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, India 3Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, India 4Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, India

Correspondence Address:
A Shirwaikar Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal - 576 104 India


A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, 'λ max of esomeprazole and domperidone respectively. Beer's law was obeyed in the concentration range of 5-20 µg/ml and 8-30 µg/ml for esomeprazole and domperidone respectively. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of esomeprazole and domperidone in combined solid dosage form.



Share this