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Assessing Dydrogesterone Efficacy in Endometrial Protection for Abnormal Uterine Bleeding due to Endometrial Hyperplasia

Author(s): Yuxiang Zhou, Xiulan Li, Yanmei Li and Qing Liu*
Department of Gynecology, Beijing Youan Hospital, Capital Medical University, Fengtai, Beijing 100069, China

Correspondence Address:
Qing Liu, Department of Gynecology, Beijing Youan Hospital, Capital Medical University, Fengtai, Beijing 100069, China, E-mail:

This study aims to assess the efficacy of dydrogesterone in protecting the endometrium in females experiencing irregular uterine bleeding secondary to endometrial hyperplasia. A cohort of 112 patients diagnosed with abnormal uterine bleeding due to endometrial hyperplasia, who underwent hysteroscopic surgery at our institution between January 2019 and May 2023, were divided into two groups. The observation group received dydrogesterone post-surgery, while the control group was treated with conventional therapy using drospirenone ethinylestradiol. Primary outcomes included symptom improvement, treatment effectiveness, and safety profiles. Secondary outcomes involved assessing health-related quality of life using the SF-36 questionnaire. Baseline characteristics were similar between groups (p>0.05). Following treatment, the observation group exhibited significantly greater improvements in symptoms and treatment effectiveness compared to the control group (p<0.05), without an increase in adverse reactions. Moreover, while both groups experienced significant enhancements in SF-36 scores from baseline, the observation group showed more pronounced improvements in certain dimensions (p<0.05). Dydrogesterone treatment following hysteroscopic surgery for females with abnormal uterine bleeding and endometrial hyperplasia demonstrates superior efficacy in endometrial protection and symptom management, without escalating adverse effects. The observed enhancements in quality of life underscore its clinical utility, suggesting dydrogesterone as a valuable therapeutic option in this clinical context.


Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report