Abstract

Natural cyclic oligosaccharides called cyclodextrins improve the bioavailability of drugs by the formation of inclusion complexes involving small and macromolecules of poorly soluble compounds in water. Cyclodextrins act as a solubilizer and targeting agent for drugs with low water solubility, enabling them to effectively target specific cells where poorly water-soluble compounds interact with the hydrophobic cavity of cyclodextrins to enhance their solubility. Cyclodextrins are effective drug delivery agents because of their essential function as complexing carriers. Various ligands can be utilized to modify the surface of cyclodextrin to actively target drugs. It is possible to consider it to have amphiphilic characteristics by enduring a chemical transformation with long aliphatic chains, and a variety of amphiphilic cyclodextrins can produce nanoparticles without the usage of surfactants. Cyclodextrin-nanocarriers act as cargo with solubilizer for drugs and a targeting agent for specific receptors present in specific cells and releases the drug. Cyclodextrins have many applications, including the reduction of drug-induced gastrointestinal discomfort, avoiding interactions between drug-drug and drug-excipient, and transforming drug products that are liquid into microcrystalline solid powders. Because of their biocompatibility and biodegradability, cyclodextrins have outstanding properties that make them particularly useful in the pharmaceutical and cosmetic industries.