Editor's Note 2020

Divakar Goli

Post-approval Change Submission: ICH Q12 Impact Analysis on India and Japan

S. Moorkoth* and T. Haldar

The present research provides a discussion on post approval change management of pharmaceuticals, biologics and drug device combinations, which is an important part of life cycle management...

The Ginger Prophecy; A Review of the Underexplored Genus, Hedychium against Cancer

P. Verma and R. Kundu*

Cancer, the seventh most fatal disease in the world, poses a long struggle to combat this deadly disease. Economically and pharmacologically important members of Zingiberaceae plant family h..

Design, Synthesis and Antiinflammatory Evaluation of 5(6)-(un)-substituted-1H-Benzimidazol-2-ylthioacetylpiperazine Derivatives

L. V. Ganji and P. N. Agrawal

Benzimidazole-2-thione derivatives are known to possess broad spectrum of biological activities, and the most prominent being the antiinflammatory activity. The synthesis of these compounds ..

Preparation and Evaluation of Rosuvastatin Calcium Nanosuspension and Solid Dispersion Tablets by Wet Granulation and Direct Compression Techniques using Tamarind Gum as a Binder

S. Arjun, S. Karthik, K. Arjunan, S. Hariharan, P. Seenivasan and V. Sankar*

The current investigation was attempted to enhance the solubility and dissolution of rosuvastatin calcium through nanosuspension and solid dispersion techniques using tamarind gum as a binde..

Synthesis, Biological Evaluation and Molecular Docking Studies of Novel 1,8-Naphthyridine-3-carboxylic Acid Derivatives as Potential Antimicrobial Agents (Part-1)

V. K. Gurjar, D. Pal*, A. Mazumder and R. Mazumder

Synthesis and investigation of antimicrobial activity of 6 novel 1,8-naphthyridine-3-carboxylic acid derivatives are presented. Among the derivatives, compounds 4a–5b2 showed a broad-s..

Lyophilized Ethinylestradiol Nanosuspension: Fabrication, Characterization and Evaluation of in vitro Anticancer and Pharmacokinetic Study

T. A. Powar, and A. A. Hajare*

The present investigation was aimed to fabricate lyophilized nanosuspension of poorly soluble ethinylestradiol in order to enhance oral bioavailability and stability. The top-down high-press..

SDF-1 Improves Renal Fibrosis in Type 2 Diabetes Mellitus Involving TGF-beta-mediated ECM via PI3K/AKT Signaling

J. Xie, Ji Zhang and H. Shuai*

The present study investigated the role of stromal cell-derived factor-1 in the progression of renal injury in type 2 diabetic nephropathy. The 8-week old male db/db mice were used as the mo..