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Review Article p. 184

An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress

DEEPA SUGUMAR, J. SARAVANAN *, R. EMDORMI AND T.K. PRAVEEN

A wide range of experimental and observational studies have established the irrefutable role of oxidative stress in the pathogenesis of a plethora of diseases either directly or indirectly. ..

Review Article p. 193

Augmentation of Mast Cell Stability, a Therapeutic Strategy for Idiopathic Pulmonary Fibrosis

S. M. ABDULLAH AND *P. M. MAZUMDER

Idiopathic pulmonary fibrosis is a continuous deteriorating type of interstitial lung disease. In clinical practice, inhibition of fibrotic progression is essentially required. Currently ava..

Research Article p. 203

Quality by Design Based Development and Optimization of A Novel, Dual Wavelength HPLC Method for Determination of Impurities in Piribedil Prolonged Release Tablets

N. KUMAR*, AND SANGEETHA DHARMALINGAM

Piribedil is an antiparkinson agent, available as Clarius Prolonged release tablet in Germany. No analytical method is reported for estimation of impurities in Piribedil. The objective of th..

Research Article p. 216

Formulation and in vitro Characterization of Time Release Tablets of Propranolol Hydrochloride

S. GIRI AND S. MOHAPATRA

The objective of this investigation was to prepare and evaluate propranolol hydrochloride time release tablets using press coating technique. The time release tablet consisted of two layers,..

Research Article p. 222

Synthesis and Evaluation of Disubstituted Benzimidazole Derivatives as Potential Analgesic and Antidiarrheal Agents

POUSHALI SAHA, SHEJUTI RAHMAN BRISHTY AND S. M. ABDUR RAHMAN*

The present study is aimed at the synthesis and biological evaluation of a variety of disubstituted benzimidazole derivatives. The disubstituted benzimidazoles, identified as 3a, 3b, 3c, and..

Research Article p. 230

Doxorubicin-Bioconjugated Cadmium Sulfide Dextrin Quantum Dots for Imaging Cells

G. GONZALEZ DE LA CRUZ *, P. RODRIGUEZ-FRAGOSO, A. MASTACHE-JUAREZ , J. REYES-ESPARZA AND L. RODR?GUEZ-FRAGOSO LOURDES

In this investigation, quantum dots of cadmium sulfide semiconductor crystals capped with dextrin and bioconjugated with doxorubicin were used to target and provide imaging of HeLa cells, wh..

Research Article p. 242

Morin Attenuates Interleukin-1?-Induced Inflammatory Response in Primary Rat Chondrocytes by Suppressing the Overproduction of Nitric Oxide and Matrix Metalloproteinases

JING SHI*, WEI YAO AND SHILEI PANG

The present investigation was aimed to evaluate the antiosteoarthritic effect of morin in isolated primary rat chondrocytes in the presence of interleukin-1β. Results obtained showed th..

Research Article p. 249

Enhancement of the Physicochemical Properties of Poorly Soluble Lovastatin by Co-crystallization Techniques - In vivo Studies

GADDAM MADHURI, R. NAGARAJU AND K. N. KILLARI

To overcome the poor solubility and low bioavailability of lovastatin co-crystallization was attempted. Lovastatin co-crystals were prepared with selected co-former gallic acid by co-grindin..