Schiff bases of anthramilic acid (1-5) and their corresponding cycloaddition products (6-10) were synthesized and evaluated for their anti-inflammatory activity against carrageenin induced oedema in albino rats in a dose of 50 mg/Kg oral. All the compounds of the series showed anti-inflammatory activity. Compound 2, N-O-methoxyphenyl benzylidene anthranilic acid and compound 7, 1-(2-carboxy-phenyl)-3-chloro-4-(2-methoxyphenyl) azetidin-2-one exhibited promising activity. So these compounds were compared with phenylbutazone for their relative potency. Moreover, this compound was also investigated for ED50, ulcergenic liability, central nervous system (CNS) and cardiovascular effects and acute toxicity studies.

Mannich bases of Mebendazole were synthesized and the formation of the products was confirmed by analytical and spectral data. Anthelmintic activity of the synthesized compounds was evaluated by in-vivo method using Ancylostoma ceylanicum (hook worms ) infection in hamsters. Only one compound M8 Methyl-N-(morpholinomethyl)-5-benzoyl-1H-benzimidazol-2yl carbamate has shown comparable anthelmintic activity with Mebendazolematm10 mg/Kg x 1 dose level.

Commercial antacid products containing magaldrate were evaluated. The tablets were found to be less effective than the suspensions. A wide variation in the activity was also noted amongst the suspensions.

Various mature plant parts (seeds, stem and leaves) of Dolichos Lablab L. were collected locally. Unorganised callus tissue of D. lbalab raised and maintained by frequent subculturings on revised Murashige and Skoog's medium suplemented with 1 ppm of 2, 4-D and 1 agar (RT) have been analysed for their sterol contents. Four sterols were persent in vivo and in vitro.

Solvent deposited (SD) systems of ketoprofen using five excipients showed marked increase in the dissolution rate and efficiency. Water insoluble excipients gave fast dissolution when compared to water soluble excipients.

Among 28 Medicinal plants screened for in vitro antifilarlal activity Anacardium occidentale was the most active. The antifilarial activity was due to the phenolic compound cardol which was more potent and less toxic when compared to other phenolic compounds.

Phytochemical investigations of the dried flowers of Butea frondosa Roxb revealed the presence of atleast seven flavones and flavanoid constituents including butrine and isobutrine and also four free amino acids. Purified alcholic extract at lower dose level and etherial and water extracts at higher dose level have been found to exhibit significant antioestrogenic activity in immature mice, while ethyl acetate extract containing butrine and isobutrine exhibit poor activity. Significant inhibition of uterus weight gain, vaginal epithelium cornification and characteristic histological changes have been observed.

A method for the routine analysis of major opium alkaloids, morphine, codeine, thebaine, papayerine and narcotine, in poppy straw samples is described. Recovery of alkaloids obtained was better when the sample was extracted with 2.5 percent aqueous acetic acid and lime and mobile phase-A was used as eluting solvent.

Theophylline was microencapsulated with cellulose acetate by a complex emulsion method and the microencapsulated were studied. Controlled drug release which depended on percent coat material and size of the microcapsules and good correlation between percent coat material and T50 value were observed. Drug release mechanism was found to be of diffusion type. Release followed first order kinetics.

Cinnamyyl phenols (or benzyl styrenes) and some neoflavonoids have been found to possess pronounced microbicidal properties. In view of this 8-cinnamyl and 6, 8-dicinnamy derivatives (III) and (II) of 5, 7-dihydroxychromone (I), have been synthesized and evaluated for antibacterial activity.