5-[2-Hydroxy phenyl]-1,3,4-oxadiazole-2 (3H) thione (II) was synthesized by cyclization of salicylic acid hydrazide (I). II was further converted to 5-[2-hydroxy phenyl ]-3-[arylaminomethyl)-1,3,4-oxadiazole 2(3H) thiones (III) and their hydrochlorides (IV). All the compounds were evaluated for their ability to inhibit carrageenin induced rat's paw oedema. IIIc and IIIe were found to have better activity than phenylbutazone with higher ALD 50 values.

Condensation of phenyl hydrazine with acetophenone gives acetophenone phenyl hydrazone (I) which cyclises to 2-phenyl-indole (II) in the presence of anhydrous ZnCl2. Interaction of (II) with phosphorous oxychloride in DMF solvent affords 2-phenyl-indole-3-aldehyde (III). The reaction of (III) with acetic anhydride in the presence of sodium acetate furnishes 2-methyl-4-(2'-phenyl-indole-3'-yl)-methylene oxazole-5-one (IV). Condensation of (IV) with 2-amino 5-alkyl, 1,3,4-thiadiazoles affords 1-2'-5(5(-alkyl-1',3',4'-thiadiazolyl) -2-methyl-4-(2"-phenyl-indole-3'-yl-methylene-imidazole-5-ones. Some of the compounds show promising CNS, CVS and anti-inflammatory properties. The present paper describes the synthesis along the following route.

Abietic acid was isolated from rosin N Grade. Abietic acid-sorbitol derivatives were prepared and evaluated for their physicochemical properties and as material for microencapsulation by pan coating technique, using salicylic acid as a model drug. The coated microcapsules were evaluated for moisture absorption, flow properties, friability and release characteristics. The result showed that the materials having lower acid values possedd moisture protection properties and also prolong the release of the drug.

The solubilities of ultraviolet light absorbers, Uvinul D-50 and Uvinul N-35 in aqueous solutions of polyoxyethylene glycol ether nonionic surfactants of varying chain length have been studied at 25. The solubility data and the absorption spectra in aqueous surfactant solutions and other solvents suggest that the solubilization of Uvinul D-50 occurs predominantly in the polyoxyethylene region of the micelle while Uvinul N-35 is distributed between this region and the hydrocarbon interior.

Spectrophotometric method for quantitative determination of total Bacosides as Bacoside-A (the active constituent) - a mental retention capacity enhancer is reported.

Tablets of Sodium Fluoride (NaF) were prepared by wet granulation method using Carboxy Methyl Cellulose (CMC) and 10 percent starch paste as matrix material and binding agent. Compressed tablets were evaluated for various physical parameters.

Differential pulse polarography has been employed for the determination of diazepam in pharmaceutical formulations. The well defined peaks used for analytical purposes were those produced by the 2e-, reduction of the azomethine group. Analytical procedure has been described for the determination of the drug. (Standard diviation : 1.2 percent Correlation coefficient : 0.968 and detection limit : 2.4 x 10(-7)M).

Some new chlorosubstituted phenoxy acetyl and propionyl benotriazoles were synthesised and screened for their anti-inflammatory, analgesic, antibacterial and antifungal properties. Trichlorophenoxy acetyl benzotriazole exhibited better anti-inflammatory activity than its propionyl derivative. The 2,5-dichlorophenoxy acetyl bbenzotriazole showed moderately better analgesic activity among the series. All the compounds showed mild to moderate antibacterial and antifungal activity.

Spectrophotometric studies of the mucilage, designated as Drum stick polysaccharide (DSP), isolated from the pods of Moringa pterygosperma Gaertn, revealed the presence of galactose, dextrose, xylose and sodium, potassium, magnessium, calcium salts of glucuronic acid. Contrary to the definition of mucilages, the presense of dextrose was an exception in the present case.

Dispersible tablets of three poorly soluble drugs namely sulphamethoxazole, piroxicam and oxyphenbutazone formulated with potato starch and MCC fulfilled all official (B.P.) requirements and gave fast and rapid dissolution of the medicament. Dissolution followed first-order kinetics.

N1-Aryl-N3-(5-aryl-1, 3, 4-oxadiazol-2-yl) thioureas (II a-d) on cyclocondensation with CS2/KOH and ethyl chloroformate afford 2, 6-diaryl-1, 3, 4-oxadiazolo [3, 2-a]-s-triazine-5, 7-dithiones (III a-d) and their - thionones analogues (IV a-d) respectively. 2, 6-Diaryl-5-thioxo-1, 3, 4-oxadiazolo [3, 2-a]-s-triazin-7-ones (VI a-d) are obtained by trating oxadiazolycarbamates (V a-b), the condensation products of 1, 3, 4-oxadiazoles and ethyl chloroformate, with aryl isothiocyanates. The compounds II to VI have been screened for their antifungal activity against A. flavus and F. solani.

The anticancer principle from Saraca asoca flowers indicated 50 percent cytotoxicity (in vitro) in Dalton's lymphoma ascites and Sarcoma-180 tumour cells at a concentration of 38 mug and 54 mug repectively, with no activity against normal lymphocytes but preferential activity for lymphocytes derived from leukemia patients (ALL). Tritiated thymidine incorporation studies in dicate the mechanism of action of the agent at the site of DNA synthesis.

The differential pulse polarographic behaviour of dantpolene has been investigated over the pH range 2.0 to 12.0. The best defined peaks for the determination of the title compound are obtained in the buffer of 4 greater than pH less than 6. This technique has been applied to the determination of dantrolene in pharmaceutical formulations. Both standard addition and calibration methods are used. The lower detection limit is found to be 25 ngml(-1). The method is accurate and reproducible with 98.9 percent - 99.6 percent +/- 0.7.

A simple colorimetric method is described for the determination of diclofenac sodium in pharmaceutical formulation based on the reaction of the drug in acidic media with sodium cobalti nitrite to form a light yellow colored complex ( lambda max 368 nm ) which obeys Beer's Law in 25 - 125 mug/ml concentration range.