Synthesis of di-and trisubsituted pyrido[2,3-d] pyrimidines has been performed by the chemical transformation of 2,3,4,6,-tetrasubstituted pyridine with formamide, urea and different arlisocyanates. The authenticity of the products was established with the help of elemental analyses, IR and NMR spectral data. All of the synthesized compounds have antimicrobial activity.

Some new α-(2-phenyl-4-arylidene-5-imidazolinon- l-yl-amino carbonylmethyl thio)- α,β-bisbenzimidazol-2’, 2’-ethane and α-(4-aryl-3-chloro-2-azetidinon-l-yl-amino-carbonylmethyl thio) – α,β-bisbenzimidazol-2,2’-yl- ethane were synthesised. The products have been characterised by IR, PMR, Mass spectra and elemental analyses. The Products have been screened for antimlcrobial activity. Some of the products exhibited comparable activity with standard drugs at same concentration.

Quininone oxime when refluxed with phosphorus pentachloride in chloroform for 90 minutes underwent Beckmann fragmentation rather than rearrangement to give 4-cyano-6-methoxyquinoline.

Resealed erythrocytes as carriers for salbutamol sulphate were prepared as a novel drug delivery system for controlled release therepy by hypotonic haemolysis technique. In vitro drug release study was carried out by dialysis technique. The product was lyophillised. In vivo studies in guinea pigs using histamine chamber showed promising results.

3-[4-(3-(Substituted aryl)-1-oxo-2-propenyl]phenyl] sydnones were condensed with hydrazine to yield fifteen 3-[4-(4,5-Dihydro-5-(substituted aryl)-1H-pyrazol-3-yl]phenyl]sydnones. Three compounds have shown anti-inflammatory activity in carrageenan induced edema assay in rats and five compounds have shown analgesic activity in acetic acid-induced writhing assay in mice at 100 mg/kg dose p.o. respectively. Compound 24 exhibited both antiinflammatory and analgesic activity, which appeared to be similar to those produced by the standards phenylbutazone and aspirin. However compound 21 showed more analgesic activity than aspirin (ED50, 25.0mg/kg, 81.4mg/kg)

Simple and rapid colorimetric and photometric titration procedures for the determination of dimercaprol in injection have been developed. They are based on the formation of yellowish brown colour instantaneously, on mixing dimercaprol with cobalt (II) acetate in dimethylformamide.

A series of 2-aryl-3-[(3’5’-dinitrobenzamido)]-thiazolidin-4-ones and N-[3’5’-dinitrobenzamido]-3-chloro-4-(aryl substituted) azetidin-2-ones have been prepared and examined for antibacterial and antifungal activity in vitro against E.coli (gram negative), S. aurus (gram positive) and A.niger, A. flavous respectively. The reaction of 3,5-dinitrobenzoic acid with thienyl chloride in the presence of dry methanol yields 3,5-dinitro-benzoate, on condensation with various aromatic aldehyde gave 2-(3’5’- dinitrobenzoyl) hydrazones, which on cycle-addition with thioglycollic acid and chloracetyl chloride gave 2-aryl-3-[(3’5’-dinitrobenzamido)]-thiazolidin-4-ones and N-[3,5,- dinitrobenzamido] –3-chloro-4-(aryl substituted)-azetidine-2-ones respectively.

Arteether is an artemisinin derivative for treatment of cerebral malaria. Arteether has two isomers α and β. It is now undergoing clinical trials at C.DR.I., Lucknow. Arteether has no U. V. absorption above 220nm. Therefore it was treated with 1N HCL which gives two specific U. V. absorption maximum at 256 nm and the other at 310 nm.

Cassia biflora has been shown to contain chrysophanol, physcion and luteolin. It has been observed that anthraquinones lacking vicinal hydroxyls do not respond to colour reaction with alcoholic Ferric chloride.

Diosgenin content in the roots of Piper betle was estimated by GLC and was found to be 0.08% on dry wt basis. The roots, a waste by-product obtained during replantation of the crop, can be tapped as cheaper source of diosgenin and may prove a boon for commercially limping betelvine industry.